Figure 6.

Relative cardiosafety ranking of Screen-Well^™ Cardiotoxicity Library drugs. ToxPi scores (see Supplemental Tables 5 and 6) were used to create a relative ranking of screened drugs using multiparametric data collected from 30 min (A) and 24 hr (B) time points. Note that cell viability data for 30 min time point was collected 24 hrs after addition of chemicals to cells. Blue squares – non-toxic drugs, red squares – cardiotoxic drugs. Representative ToxPi-es for two non-toxic and two cardiotoxic compounds are shown to visualize the relative contribution of each parameter (represented in colors of each slice) to the overall score of a compound.