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. 2013 Nov 19;1(1):2–14. doi: 10.1002/acn3.19

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© 2013 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Long-term tissue and neurological outcome. (A) Vehicle or KD025 was administered (arrows) starting 1 h after fMCAO for a total of four doses, followed by tissue outcome assessment at 4 weeks. (B) Representative hematoxylin/eosin-stained coronal cryosections and ipsilateral and contralateral hemispheric volumes show tissue loss and atrophy at 4 weeks after stroke in vehicle-or KD025-treated mice (n = 6 and 9, respectively). Substantial atrophy was present in ipsilateral hemisphere compared with contralateral. KD025 reduced the amount of tissue loss. *P < 0.05 versus vehicle. Boxes, median, and interquartile range; whiskers, min–max; +, mean. Two-way ANOVA followed by Sidak’s multiple comparisons test. (C) The improvement in neurological function, assessed by the time to remove an adhesive tape from the contralateral forepaw, did not reach statistical significance between vehicle-and KD025-treated mice (n = 17 each). Mean ± SEM. Two-way ANOVA for repeated measures.