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. 2013 Nov 19;1(1):2–14. doi: 10.1002/acn3.19

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© 2013 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Efficacy in female, aged and diabetic mice. (A) Vehicle or KD025 administration (arrows) was started 1 h after fMCAO and continued until tissue outcome assessment at 48 h (four doses). (B) Infarct volumes (indirect method) after vehicle or KD025 (200 mg/kg) in female (n = 9 each), aged (12 months; n = 6 each) and diabetic (db/db) mice (n = 6 and 8, respectively). One db/db mouse in the vehicle group was excluded at the time of surgery due to technical failure. *P < 0.05 versus vehicle. Boxes, median, and interquartile range; whiskers, min–max; +, mean. Unpaired t-test.