Table 1.
ROCK1 versus ROCK2 selectivity of KD025 in comparison with Y27632 and fasudil.
| KD025 | Y27632 | Fasudil | |
|---|---|---|---|
| ROCK2 Ki (nmol/L) | 41 ± 2 | 77 ± 5 | 112 ± 8 |
| ROCK1 Ki (nmol/L) | >10,000 | 68 ± 2 | 145 ± 7 |
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