CHART 1.

Interactions of itraconazole with other drugs

Drugs with increased plasma con- centration	Drugs that reduce itraconazole plasma concentration	Drugs that increase itra- conazole plasma con- centration
Vinca alkaloids, alfentanyl, alprazolam, astemizole, atorvastatin calcium channel blockers, bromperidol, buspirone, cerivastatin, cyclosporine, sapride, delavirdine, diazepam, digoxin, phenytoin, indinavir, loratadine, lovastatin, midazolam, pimozide, quinidine, ritonavir, saquinavir, sildenafil, simvastatin, sulfonylureas, tacrolimus, triazolam, warfarin, verapamil	H2 receptor blockers, proton pump blockers, simultaneous antacids, simultaneous didanosine (buffered), carbamazepine, phenobarbital, phenytoin, rifampin, rifabutin, isoniazid, nevirapine	Clarithromycin, indinavir, ritonavir