CHART 1.
Diagnostic criteria of BSCL
| Major Criteria | Minor Criteria |
| • Lipoatrophy affecting the trunk, limbs, and face | • Hypertrophic cardio- myopathy |
| • Acromegalic appearance (gigantism, prog- nathism, muscle hypertrophy leading to an athletic appearance, advanced bone age, increased size of hands and feet, clitorome- galy or increased size of external genitalia in men | • Mild (IQ, 50-70) to moderate psychomo- tor retardation (IQ*, 35-50) |
| • Hepatomegaly | • Hirsutism |
| • Increased serum triglycerides (sometimes associated with hypercholesterolemia) | • Early puberty in girls |
| • Insulin resistance (increase in serum C- peptide and insulin levels)\acanthosis nigricans | • Bone cysts |
| • Phlebomegaly |
Source: Khandpur S, et al. 6
*
IQ: intelligence quotient.