Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 23;10(1):e1004010. doi: 10.1371/journal.pgen.1004010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

Elevated PC(O-16:0/2:0) levels result in an increase in LCB(P) and ceramide species (I) which is associated with an altered localization of Mss4 and PtdIns (4,5)P₂ (II) resulting in relocalization of Slm1, and presumably Slm2, from eisosomes to the PES (III) and a loss in TORC2-dependent Ypk1 phosphorylation without disrupting complex integrity (IV). Further work will be needed to determine if TORC2 components and/or Ypk1 are similarly recruited to the PES.