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Striatal serotonin is increased in Parkin−/−DJ-1−/− and Parkin−/−DJ-1−/−Gpx1−/− mice. Levels of striatal serotonin (5-HT) measured by HPLC with electrochemical detection. Separate cohorts of mice were analyzed at ages 6 (A), 12 (B) and 18 (C) months, n=6-11 mice per genotype at each age. Bars show the mean ± SEM of the level of serotonin measured from microdissected striatum. *p<0.05, one-way ANOVA compared to wild-type mice at the same age.
