Table 3. Genotype frequencies in HBV carriers, resolved HBV and uninfected subjects in Thailand.
| HBV carriers vs. Resolved | HBV carriers vs. Uninfected | |||||||
| SNP | Genotype | HBV carriersa (n = 449) | Resolved (n = 113) | Uninfected (n = 123) | OR (95% CI) | P values | OR (95% CI) | P values |
| rs3077 | CC | 259 (57.7%) | 43 (38.1%) | 57 (46.3%) | 1.00 | - | 1.00 | - |
| HLA-DPA1 | CT | 153 (34.1%) | 56 (49.6%) | 46 (37.4%) | 0.45 (0.29–0.71) | <0.001 | 0.73 (0.47–1.13) | 0.161 |
| TT | 37 (8.2%) | 14 (12.4%) | 20 (16.3%) | 0.44 (0.22–0.88) | 0.018 | 0.41 (0.22–0.75) | 0.003 | |
| Dominant b | 0.45 (0.30–0.69) | <0.001 | 0.63 (0.42–0.95) | 0.025 | ||||
| HWEp | 0.038 | 0.516 | 0.049 | |||||
| rs9277378 | GG | 242 (53.9%) | 40 (35.4%) | 48 (39.0%) | 1.00 | - | 1.00 | - |
| HLA-DPB1 | AG | 177 (39.4%) | 61 (54.0%) | 54 (43.9%) | 0.48 (0.31–0.75) | 0.001 | 0.65 (0.42–1.00) | 0.051 |
| AA | 30 (6.7%) | 12 (10.6%) | 21 (17.1%) | 0.41 (0.20–0.87) | 0.018 | 0.28 (0.15–0.54) | <0.001 | |
| Dominant | 0.47 (0.31–0.72) | <0.001 | 0.55 (0.36–0.82) | 0.003 | ||||
| HWEp | 0.757 | 0.110 | 0.390 | |||||
| rs3128917 | TT | 99 (22.0%) | 29 (25.7%) | 38 (30.9%) | 1.00 | - | 1.00 | - |
| HLA-DPB1 | TG | 241 (53.7%) | 60 (53.1%) | 48 (39.0%) | 1.18 (0.71–1.94) | 0.525 | 1.93 (1.19–3.13) | 0.008 |
| GG | 109 (24.3%) | 24 (21.2%) | 37 (30.1%) | 1.33 (0.73–2.44) | 0.355 | 1.13 (0.67–1.92) | 0.648 | |
| Dominant | 1.22 (0.76–1.97) | 0.413 | 1.58 (1.02–2.46) | 0.042 | ||||
| HWEp | 0.117 | 0.496 | 0.015 | |||||
| rs1419881 | TT | 162 (36.1%) | 31 (27.4%) | 30 (24.4%) | 1.00 | - | 1.00 | - |
| TCF19 | TC | 213 (47.4%) | 61 (54.0%) | 60 (48.8%) | 0.67 (0.41–1.08) | 0.097 | 0.66 (0.41–1.07) | 0.088 |
| CC | 74 (16.5%) | 21 (18.6%) | 33 (26.8%) | 0.67 (0.36–1.25) | 0.210 | 0.42 (0.24–0.73) | 0.002 | |
| Dominant | 0.67 (0.42–1.06) | 0.084 | 0.57 (0.36–0.90) | 0.015 | ||||
| HWEp | 0.778 | 0.349 | 0.792 | |||||
| rs652888 | TT | 169 (37.6%) | 50 (44.2%) | 57 (46.3%) | 1.00 | - | 1.00 | - |
| EHMT2 | TC | 231 (51.4%) | 50 (44.2%) | 48 (39.0%) | 1.37 (0.88–2.12) | 0.162 | 1.62 (1.05–2.50) | 0.027 |
| CC | 49 (10.9%) | 13 (11.5%) | 18 (14.6%) | 1.12 (0.56–2.22) | 0.756 | 0.92 (0.49–1.70) | <0.001 | |
| Dominant | 1.31 (0.87–2.00) | 0.198 | 1.09 (0.65–1.82) | 0.080 | ||||
| HWEp | 0.022 | 0.926 | 0.142 | |||||
Abbreviation: CI, confidence interval; OR, odds ratio ; HWEp, Hardy-Weinberg equilibrium analysis.
a
Defined as the combination between HCC and CHB.
b
Defined as a minor dominant according to the comparison between heterozygous+minor homozygous genotype and major homozygous genotype (eg. rs3077; CT+TT vs. CC).