Table 4.
Genotypic and allelic distribution of LEPR Gln233Arg, LEP G2548A, and BDNF Val66Met polymorphisms in MS and control subjects
|
MS n (%) |
HWE of MS p-value a | Control n (%) | HWE of control p-value* | Genotypic or allelic p-value b | |
|---|---|---|---|---|---|
|
LEPR
Gln233Arg | |||||
| Genotype | |||||
| Arg/Arg |
20 (12.5) |
0.399 |
17 (10.5) |
0.295 |
0.044* |
| Arg/Gln |
80 (50.0) |
(df = 1) |
62 (38.3) |
(df = 1) |
|
| Gln/Gln |
60 (37.5) |
(χ2 = 0.71) |
83 (51.2) |
(χ2 = 1.09) |
|
| Allele | |||||
| Arg |
120 (0.375) |
|
96 (0.296) |
|
0.034* |
| Gln |
200 (0.625) |
|
228 (0.704) |
|
|
|
LEP
G2548A | |||||
| Genotype | |||||
| A/A |
58 (36.2) |
0.638 |
55 (34.0) |
0.483 |
0.439 |
| A/G |
79 (49.4) |
(df = 1) |
75 (46.3) |
(df = 1) |
|
| G/G |
23 (14.4) |
(χ2 = 0.22) |
32 (19.7) |
(χ2 = 0.49) |
|
| Allele | |||||
| A |
195 (0.609) |
|
185 (0.571) |
|
0.321 |
| G |
125 (0.391) |
|
139 (0.429) |
|
|
|
BDNF
Val66Met | |||||
| Genetype | |||||
| Met/Met |
32 (20.0) |
0.479 |
30 (18.5) |
0.544 |
0.327 |
| Met/Val |
84 (52.5) |
(df = 1) |
75 (46.3) |
(df = 1) |
|
| Val/Val |
44 (27.5) |
(χ2 = 0.50) |
57 (35.2) |
(χ2 = 0.37) |
|
| Allele | |||||
| Met |
148 (0.463) |
|
135 (0.417) |
|
0.241 |
| Val | 172 (0.537) | 189 (0.583) | |||
Abbreviation: HWE Hardy-Weinberg equilibrium, LEP leptin gene, LEPR leptin receptor gene, BDNF Brain-derived neurotrophic factor gene.
Significant level;* = p < 0.05.
aBased on the results of chi-square test.
bBased on the results of chi-square test for the comparison between MS and control groups.