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. 2014 Jan 23;9(1):e86270. doi: 10.1371/journal.pone.0086270

Table 1. Selected Rlm1p regulated genes.

ORF Gene name S.cerevisiae ortholog Function/Description Ratio (mutant/wild-type) Rlm1 binding sequence (location upstream gene sequence)
Up- regulated genes
orf19.3374 ECE1 Unknown/Hyphal-specific cell wall protein 76 TAWWWWTAGM (−145R)
orf19.1321 HWP1 Protein binding/Hyphal cell wall protein involved in host defense 37,4 TAWWWWTAGM (−938R)
orf19.1816 ALS3 SAG1 Protein binding/Adhesin from the ALS family; role in epithelial adhesion, endothelial invasiveness 14,1 CTAWWWWTAG (−0 F; −10R); TAWWWWTAGM (−9 F;−1R)
orf19.5753 HGT10 STL1 Transporter activity/Glycerol permease involved in glycerol uptake induced by osmotic stress, during cell wall regeneration 13 TAWWWWTAGM (−204F; −976R)
orf19.1327 RBT1 Unknown/Cell wall protein with similarity to Hwp1p 10,4 -
orf19.6336 PGA25 Unknown/Putative GPI-anchored protein 8 TAWWWWTAGM (−316F)
orf19.6078 POL93 YIL080W Unknown/nucleic acid binding 7,7 -
orf19.2896 SOU1 SPS19 Oxidoreductase activity/Enzyme involved in utilization of L-sorbose 6,3 -
orf19.5741 ALS1 SAG1 Peptide binding/Adhesin; ALS family of cell-surface glycoprotein 6,2 TAWWWWTAGM (−853R)
orf19.3548.1 WH11 HSP12 Unknown/Protein expressed specifically in white phase yeast-form cells 5,4 TAWWWWTAGM (−96F;−781R)
orf19.4551 CTN1 YAT1 Transferase activity/Predicted carnitine acetyl transferase 4,9 TAWWWWTAGM (−799R)
orf19.6169 ATO1 ATO2 Unknown/Putative fungal-specific transmembrane protein 4,6 -
orf19.4393 CIT1 CIT1 Transferase activity/Protein described as citrate synthase 3,9 -
orf19.4679 AGP2 AGP2 Transporter activity/Protein described as an amino acid permease 3,8 -
orf19.385 GCV2 GCV2 Oxidoreductase activity/Glycine decarboxylase P subunit 3,7 TAWWWWTAGM (−213F)
orf19.6139 FRE7 FRE3 Unknown/Protein similar to ferric reductase Fre10p 3,2 -
orf19.5542 SAP6 BAR1 Hydrolase activity/Secreted aspartyl proteinase 3,2 -
orf19.4093 PES1 NOP7 Unknown/Pescadillo homolog required for filament-to-yeast switching 3,2 -
orf19.4211 FET3 FET3 Oxidoreductase activity/Multicopper oxidas 3,1 CTAWWWWTAG (−784F; −774R); TAWWWWTAGM (−5R)
orf19.1228 HAP2 HAP2 Unknown/CCAAT-binding factor involved in low-iron response 3 TAWWWWTAGM (−919R)
orf19.3981 MAL31 MAL31 Transporter activity/Putative high-affinity maltose transporte 2,8 CTAWWWWTAG (−665F; −655R); TAWWWWTAGM (−566R; −897R)
orf19.3265 TRM1 TRM1 Transferase activity/Protein described as an N2,N2-dimethylguanine tRNA methyltransferase 2,8 -
orf19.2606 HDA1 HDA1 Hydrolase activity/Histone deacetylase 2,8 -
orf19.2444 CHS7 CHS7 Protein binding/Protein required for wild-type chitin synthase III activity 2,7 -
orf19.5110 OPY2 OPY2 Unknown/S. cerevisiae ortholog has role in osmosensory signaling pathway, cell cycle arrest 2,6 TAWWWWTAGM (−457F)
orf19.1569 UTP22 UTP22 Unknown/Putative U3 snoRNP protein involved in rRNA processing 2,6 -
orf19.6948 CCC1 CCC1 Transporter activity/Putative manganese transporter 2,5 TAWWWWTAGM (−209R)
orf19.5170 ENA21 ENA2 Unknown/Similar to S. cerevisiae sodium transporters 2,5 -
orf19.651 LYP1 LYP1 Unknown/Putative permease, animo acid transmembrane transporter 2,4 -
orf19.473 TPO4 TPO4 Transporter activity/Putative sperimidine transporter 2,4 TAWWWWTAGM (−532R)
orf19.5595 SHE3 RNA binding/mRNA-binding protein that localizes specific mRNAs to daughter yeast-form cells and to hyphal tips 2,3 TAWWWWTAGM (−546R)
orf19.5338 GAL4 GAL4 Transcription regulator activity/Transcription factor involved in control of glycolysis 2,3 -
orf19.4655 OPT6 OPT2 Transporter activity/Putative oligopeptide transporter 2,3 TAWWWWTAGM (−834F)
orf19.1743 ACS1 ACS1 Ligase activity/Putative acetyl-CoA synthetase 2,3 -
orf19.6577 FLU1 TPO1 Transporter activity/Multidrug efflux pump of the plasma membrane 2,2 TAWWWWTAGM (−840F)
orf19.3974 PUT2 PUT2 Oxidoreductase activity/delta-1-pyrroline-5-carboxylate dehydrogenase 2,2 -
orf19.918 CDR11 PDR5 Transporter activity/Putative transporter of PDR subfamily of ABC family 2,1 -
orf19.6514 CUP9 CUP9 Unknown/sequence specific DNA binding 2,1 -
orf19.5071 NRP1 NRP1 Unknown/Nucleic acid binding 2,1 -
orf19.4815 YTM1 YTM1 Unknown/Protein similar to S. cerevisiae Ytm1p, involved in biogenesis of the large ribosomal subunit 2,1 -
Down-regulated genes
orf19.2525 LYS12 LYS12 Oxidoreductase activity/mitochondrial homoisocitrate dehydrogenase −20,1 -
orf19.1868 RNR22 RNR2 Unknown/ribonucleoside diphosphate reductase −3,4 -
orf19.866 RAD32 RAD30 Nucleotidyl transferase activity/Protein similar to S. cerevisiae protein with role in nucleotide excision repair −2,9 -
orf19.7600 FDH3 SFA1 Oxidoreductase activity/Putative protein of glycine catabolism −2,9 -
orf19.3749 IFC3 OPT2 Transporter activity/Oligopeptide transporter −2,7 -
orf19.2770.1 SOD1 SOD1 Oxidoreductase activity/Cytosolic copper- and zinc-containing superoxide dismutase −2,6 -
orf19.5248 MSO1 Unknown/Unknown −2,5 -
orf19.1756 GPD1 GPD1 Oxidoreductase activity/Glycerol-3-phosphate dehydrogenase (enzyme of glycerol biosynthesis) −2,5 -
orf19.5025 MET3 MET3 Transferase activity/ATP sulfurlyase of sulfate assimilation −2,4 -
orf19.4777 DAK2 DAK2 Unknown/Dihydroxyacetone kinase −2,4 -
orf19.4664 NAT4 NAT4 Transferase activity/Histone acetyltransferase −2,4 -
orf19.6640 TPS1 TPS1 Transferase activity/Trehalose-6-phosphate synthase −2,3 -
orf19.6116 GLK4 GLK1 Hexokinase activity/Glucokinase −2,3 TAWWWWTAGM (−9R)
orf19.5228 RIB3 RIB3 Lyase activity/3,4-Dihydroxy-2-butanone 4-phosphate synthase −2,3 TAWWWWTAGM (−756R)
orf19.2341 HNT1 HNT1 Hydrolase activity/Protein kinase C inhibitor-I −2,3 -
orf19.5001 CUP2 HAA1 Unknown/Protein required for normal resistance to copper −2,2 TAWWWWTAGM (−593R)
orf19.7479 NTH1 NTH1 Hydrolase activity/Neutral trehalase −2,1 -
orf19.5000 CYB2 CYB2 Oxidoredutase activity/Cytochrome b2 precursor protein −2,1 -
orf19.3359 ARP8 ARP8 Hydrolase activity/Chromatin-remodeling enzyme complex protein −2,1 -