Figure 8. Schematic diagram of the structure of the EDNRB2 protein.

Black circles indicate the positions of amino acid substitution in the mo^w and mo alleles. The Cys244Phe substitution in the mo^w allele was located in the extracellular loop between the putative fourth and fifth transmembrane (TM) domains of EDNRB2. The other three substitutions were identified at the mo locus: Thr8Ile and Thr15Ala in the N-terminal amino acids that constitute the cleaved peptide signal, and Arg332His in the sixth TM domain. The Arg332His substitution of EDNRB2 was previously reported in the panda (s/s) plumage mutant of Japanese quail (Miwa et al., 2007). The grey-shaded rectangles represent the TM domains.