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. 2014 Jan 16;63(2):585–595. doi: 10.2337/db13-0666

Figure 5.

Figure 5

Pancreas-specific deletion of SH2B1 impairs glucose tolerance. A–C: PKO (n = 16–19) and control male mice (n = 29) were fed a normal chow diet. Overnight fasting blood glucose (A) was measured and ITTs (insulin: 1 unit/kg body wt) (B) and GTTs (d-glucose: 2 g/kg body wt) (C) were conducted at 7–8 weeks of age. D–F: Male mice (7–8 weeks) were fed an HFD (60% fat) for 10 weeks. ITTs (insulin: 1 unit/kg body wt) (D) and GTTs (d-glucose: 1 g/kg body wt) (E) were performed. Control: n = 10; PKO: n = 9. F: Mice were fasted for 24 h and injected with d-glucose (3 g/kg). Plasma insulin was measured 0, 5, and 30 min after injection. Control: n = 6; PKO: n = 8. Data are means ± SE. *P < 0.05. Con, control.