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Delayed cell-cycle entry of β-cells in old age. Six-month-old mice were injected with GKA, killed at different time points later, and the fraction of Ki67+ β-cells was determined. There is no increase in the fraction of replicating β-cells 8 h after drug administration, a time point showing a robust increase in Ki67 staining in 5-week-old mice. **P < 0.01. NS, not significant.
