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. 2014 Jan 16;63(2):596–604. doi: 10.2337/db13-0462

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© 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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TCR-Vβ13⁺ T cells increase in abundance during diabetes progression in LEW.1WR1 islets. To determine the relative abundance of Vβ13⁺ T cells in the islet during progression to diabetes, we measured TCR-Vβ13 transcript abundance and normalized this to the abundance of TCR-Cβ transcripts. This measure gives us the percentage of TCR transcripts that are Vβ13⁺. There is a strong positive trend in Vβ13 transcript abundance with a significant increase on day 10 in both the diabetic (P = 0.02) and nondiabetic (P = 0.001) islet. N = 3–5 rats per time point, 29 rats total. D, day; diab, diabetes.