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. 2014 Jan 16;63(2):785–790. doi: 10.2337/db13-0893

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© 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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The effect of different GLP-1 regimens on postprandial glycemia and insulinemia. A: There was an effect between infusions (P < 0.001). Acute GLP-1 reduced postprandial glycemia (AUC_0–60) compared with placebo (*P = 0.001), as did intermittent compared with prolonged (#P = 0.007), but there was no difference between prolonged and placebo (P = 0.21) or acute and intermittent (P = 1.0) regimens. B: There was an effect between the various infusions (P < 0.001). Postprandial insulin concentrations were reduced during intermittent compared with prolonged infusion (*P = 0.003); comparing acute infusion with placebo, the difference was not statistically significant (P = 0.07). Postprandial insulin concentrations were comparable between acute and intermittent infusions (P = 1.0) and between prolonged infusion and placebo (P = 0.21). Data are mean ± SEM. A mixed-effects maximum likelihood model was used to determine differences with post hoc testing adjusted for multiple comparisons. IV, intravenous.