Skip to main content
. 2014 Jan 23;9(1):e86806. doi: 10.1371/journal.pone.0086806

Table 4. Group transport study of NSAIDs across RBMEC.

substance PSblank PSall PScell PEall PEcell Ratio to Diazepam*
[µL/min] [µL/min] [µL/min] [µm/min] [µm/min]
RBMEC
group study Diazepam 1.93±0.13 1.29±0.02 3.77±0.16 14.35±0.20 41.92±1.75 1.00±0.00
Piroxicam 1.94±0.12 1.15±0.03 2.82±0.17 12.76±0.33 31.39±1.94 0.76±0.04
Ibuprofen 1.71±0.15 1.07±0.06 2.86±0.39 11.88±0.62 31.99±4.28 0.76±0.09
Meloxicam 1.86±0.12 0.89±0.02 1.73±0.09 9.97±0.27 19.27±0.99 0.47±0.02
Tenoxicam 1.74±0.10 0.70±0.02 1.18±0.05 7.82±0.21 13.12±0.59 0.32±0.01
Diclofenac 1.65±0.13 0.96±0.05 2.39±0.27 10.84±0.51 26.73±2.97 0.64±0.06
*

Ratio to Diazepam is calculated by average PEcell data of the investigated NSAID and the corresponding diazepam value.

Summary of permeability data of the group study with NSAIDs piroxicam, ibuprofen, meloxicam, tenoxicam and diclofenac across the RBMEC cell layers (n = 3, data are presented as means ± SD).