Table 4. Group transport study of NSAIDs across RBMEC.
substance | PSblank | PSall | PScell | PEall | PEcell | Ratio to Diazepam* | |
[µL/min] | [µL/min] | [µL/min] | [µm/min] | [µm/min] | |||
RBMEC | |||||||
group study | Diazepam | 1.93±0.13 | 1.29±0.02 | 3.77±0.16 | 14.35±0.20 | 41.92±1.75 | 1.00±0.00 |
Piroxicam | 1.94±0.12 | 1.15±0.03 | 2.82±0.17 | 12.76±0.33 | 31.39±1.94 | 0.76±0.04 | |
Ibuprofen | 1.71±0.15 | 1.07±0.06 | 2.86±0.39 | 11.88±0.62 | 31.99±4.28 | 0.76±0.09 | |
Meloxicam | 1.86±0.12 | 0.89±0.02 | 1.73±0.09 | 9.97±0.27 | 19.27±0.99 | 0.47±0.02 | |
Tenoxicam | 1.74±0.10 | 0.70±0.02 | 1.18±0.05 | 7.82±0.21 | 13.12±0.59 | 0.32±0.01 | |
Diclofenac | 1.65±0.13 | 0.96±0.05 | 2.39±0.27 | 10.84±0.51 | 26.73±2.97 | 0.64±0.06 |
Ratio to Diazepam is calculated by average PEcell data of the investigated NSAID and the corresponding diazepam value.
Summary of permeability data of the group study with NSAIDs piroxicam, ibuprofen, meloxicam, tenoxicam and diclofenac across the RBMEC cell layers (n = 3, data are presented as means ± SD).