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. 2014 Jan 23;9(1):e87203. doi: 10.1371/journal.pone.0087203

Figure 5. Viability of NHEJ deficient cells after treatment with HDACis.

Figure 5

The indicated cells were treated for 48 µM TSA, 0 to 100 µM SAHA or 0 to 118 mM MMS. Viability was determined using CellTiter-Glo. The data represent the average of 3 independent experiments ± SD. (A) Hela cells after 24 hr transfection with either non-targeting siRNA or siRNA against KU80. (B) HCT116 LIG4-null or wild-type HCT116 cells. (C) HCC1937 cells, lacking a functional BRCA1 gene, or HC1937 cells complimented by BRCA1 cDNA expression (wild-type).