Figure 1. Treatment with H₂S attenuated TBI-induced brain edema.

(A) The water content of injured hemisphere and contralateral hemisphere were measured from 1 h-7d after TBI. *P<0.05, **P<0.01 vs. sham group. ^#P<0.05, ^##P<0.01 vs. contralateral hemisphere group at the same time point. (B) Pretreatmented H₂S at 30 min before TBI with different dosage from 0.1–45µmol/kg, and the brain water content were measured at 1d after TBI. *P<0.05 vs. TBI group. (C) Injected H₂S (1µmol/kg,) at 30 minutes before or 15 min, 30 min, 1 h, 2 h, 4 h post TBI, and the brain water content were detected at 1d after TBI. *P<0.05 vs. TBI group. Data were expressed as mean ± SEM (n  = 6).