Table 1.
Summary of all 13 cases Hepatocellular Carcinoma (HCC) with Situs Inversus Totalis (SIT)
| NO. | Year | Author/(Language) | Country | Age/Sex | Presentation | Tumour location | Size | LFT | AFP ng/ml | Viral markers | Angiography | TAE/TACE | Treatment | Other notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1983 | Kanematsu (English) [4] | Japan | 37/M | Convulsion 10 cm hepatomegaly & cirrhosis | Rt. lobe | Multifocal | N | 1,400,000 | HbsAg + | N | TACE+ | Rt. Lobectomy** | Palliative surgery |
| 2 | 1983 | Wada [22] (Japanese) | Japan | 85/M | Abdominal pain, 8 cm hepatomegaly, 15 kg wt loss | Lt. lobe | 10*8*7 cm | N | 200 | – | Tumour thrombous in PV and IVC | TACE+ | Autopsy findings | Metastasis in GB and DU, + synchronous, stomach and Prostatic CA |
| 3 | 1989 | Kim [10] (English) | Japan | 66/F | Pain 3 weeks, 6 cm hepatomegaly | Rt. lobe | 14*12 cm | N | 4,000 | HbsAg + | Anomalous left hepatic vessels. | – | Rt. Lobectomy** & B-I Gastrectomy | Synchronous Gastric malignancy |
| 4 | 1990 | Kanchira[25] (Japanese) | Japan | 59/M | – | Seg. VIII | 3 cm | N | 2,388 | Negative | Anomalous common hepatic artery | – | – | – |
| 5 | 1996 | Kamike [3] (English) | Japan | 69/F | Cirrhosis | Seg. VII | 3*2 cm | N | 291 | – | Anomalous left hepatic vessels. | TAE + | Rt. Segmentectomy | Hepatocellular & Cholengio-cellular CA component |
| 6 | 1996 | Iwakura [5] (Japanese) | Japan | 63/M | Cirrhosis | Seg. VI | 1.5*1.3 cm | N | N | HCV + | N | TAE + | Lower posterior segmentectomy | Recurrence in caudate lobe 6 months |
| 7 | 1999 | Seshimo [25] (Japanese) | Japan | 70/M | Cirrhosis | Seg. II | 2.3*2.3 cm | N | 160 | HCV + | Anomalous common hepatic artery | – | Seg II partial hepatectomy | – |
| 8 | 2003 | Cheng [13] (English) | Taiwan | 43/M | Kartagener’s syndrome | Seg. II, III, IV | 10*9*7 cm | N | 27,910 | HbsAg +, HCV + | N | TAE + | Lt. Lobectomy | GB stone, AFP 30 ng/ml after 12 months |
| 9 | 2004 | Kakinuma[20] (Japanese) | Japan | 70/F | Asymptomatic | Seg. V, VI,VIII | 2.5*2.0 cm | N | N | HCV + | N | TAE + | Seg VII partial hepatectomy | – |
| 10 | 2004 | Niki [23] (English) | Japan | 66/M | Abdominal pain 1 week | Seg. II, V | 6 cm | N | N | Negative | N | TAE + | – | Well after 12 months |
| 11 | 2006 | Swada [24] (Japanese) | Japan | 76/M | Abdominal fullness | Rt. lobe | T2 | N | 803 | Negative | N | TAE + | Hepatic trisegmentectomy | Tumour size as per TNM classification |
| 12 | 2007 | Li [21] (English) | China | 53/M | Asymptomatic | Rt. lobe | 10 cm | Abnormal | 49 | Negative | IVC continuous as Hemiazygos | TACE+ | – | Schistomiasis, well at 12 months |
| 13 | 2011 | Present case | India | 49/F | Abdominal pain | Seg. VII, VIII | 12*11*10 cm | N | N | Negative | N | Not done | Rt lobectomy | Died after 9 months |
N Normal; M Male; F Female; Rt. Right; Lt. Left; GB Gallbladder; DU Duodenum; PV Portal vein; IVC Inferior vena cava; CA Carcinoma; wk week; LFT Liver Function test; AFP Alpha fetoprotein; TAE Trans arterial embolization; TACE trans arterial Chemo embolization; Seg. = segment; HCV Hepatitis C Virus; HbsAg Hepatitis B surface antigen
**original article had mention “lt. lobectomy”