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. 2014 Jan 14;4(2):215–228. doi: 10.7150/thno.7868

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Time course of APAP toxicity of the mouse liver injured by intraperitoneal injection of 300 mg/kg APAP. (A) Histological confirmation of liver injury and recovery. Excised liver sections were and stained by hematoxylin-eosin and examined by expert pathology. Liver architecture was normal at 1 hour with microvesicular steatosis in hepatocytes surrounding central veins. The steatosis expanded at 3 hours and at 12 hours, centrilobular necrosis was apparent. At 24 hours, hemorrhage appeared. Hepatocytes started to recover at 48 hours and fully recovered at 192 hours. (B) Temporal profiles of ALT activity in plasma were observed to correlate with level of liver injury. Results are plotted as mean ± standard error (n=3). Comparisons between multiple groups were performed with one-way analysis of variance.