Table 3. 24-hour urinary isoflavonoid excretion by equol phenotype after a soy-isoflavone challenge (µmol/24 hours).
Urinary isoflavone | Equol producers (n = 104)a | Nonproducers (n = 76)a | Pb | ||
Mean ± SD | Range | Mean ± SD | Range | ||
Equol | 35.16 ± 21.76 | 1.84–121.12 | not detected | not detected | <0.001 |
Daidzein | 50.22 ± 22.15 | 2.89–103.19 | 58.01 ± 21.87 | 1.47–116.63 | 0.01 |
Dihydrodaidzein | 13.97 ± 10.87 | 0–61.05 | 23.27 ± 16.91 | 0–71.68 | <0.001 |
O-DMAc | 7.18 ± 6.29 | 0–36.04 | 11.10 ± 11.25 | 0–54.94 | 0.03 |
Genistein | 8.12 ± 6.64 | 0–37.98 | 8.26 ± 7.71 | 0.37–60.35 | 0.74 |
Dihydrogenistein | 3.49 ± 7.88 | 0–64.62 | 2.59 ± 4.40 | 0–21.32 | 0.39 |
Glycitein | 23.61 ± 9.92 | 0–47.96 | 22.54 ± 9.32 | 0.51–50.84 | 0.24 |
Dihydroglycitein | 0.46 ± 0.99 | 0–4.32 | 0.56 ± 1.38 | 0–7.26 | 0.96 |
Total isoflavoned | 142.20 ± 54.09 | 14.19–319.56 | 126.34 ± 48.67 | 2.35–306.75 | 0.04 |
aDetermined by soy-isoflavone challenge.
bEquol producers and nonproducers compared using Mann-Whitney U test.
cO-DMA: O-desmethylangolensin.
dTotal isoflavone = daidzein plus its metabolites dihydrodaidzein, equol, O-desmethylangolensin; genistein plus its metabolite dihydrogenistein; and glycitein plus its metabolite dihydroglycitein.