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. 2014 Jan 24;8:7. doi: 10.3389/fncel.2014.00007

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Copyright © 2014 Mòdol, Mancuso, Alé, Francos-Quijorna and Navarro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of microglial (Iba-1 labeled) immunoreactivity in SOD1^G93A, SCI and sciatic nerve injured mice. (A) Representative confocal images of the ventral part of the lumbar spinal cord of wild type/naïve, SOD1^G93A at 8, 12, and 16 weeks of age, SCI and sciatic nerve crush injured animals. Scale bar 10 μm. (B) Iba-1 immunoreactivity quantification revealed a progressive increase of microglial reactivity during disease progression in SOD1^G93A mice. At late stages (16 weeks of age), Iba-1 immunoreactivity level is similar to that observed in SCI and sciatic nerve injured animals. Values are mean ± s.e.m. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. respective wild type/naïve animals.