Table 3.

Comparison of GWAS results for clinical CVD traits with eQTL results

Gene	Clinical phenotype	Top1 cis-eSNP	P, cis-eSNP	Hemostatic factors (18)			Blood lipids (27)				Red blood cell traits (9)						Subclinical CAD (20)	Blood pressure (35)
				vWF	FVII	FVIII	TC	HDL	LDL	TG	HB	HCT	MCHC	MCH	MCV	RBC	CAC	SBP	DBP
Below are the P-values from previously reported GWAS results of relevant clinical traits
ABO	Hemostatic, CAD, others	rs8176731	1.12 × 10−91	1.94 × 10−8	0.91	2.83 × 10−6	6.51 × 10−8	0.21	3.45 × 10−10	0.69	0.02	0.02	0.26	0.52	0.80	0.89	0.79	0.98	0.85
FADS2	Lipid, CAD	rs968567	5.72 × 10−73	0.45	0.76	0.40	5.39 × 10−7	8.32 × 10−5	3.87 × 10−7	4.96 × 10−7	0.04	0.08	0.05	0.91	0.89	0.40	0.74	0.05	0.21
LPL	Lipid, CAD	rs6993414	1.21 × 10−52	0.68	0.36	0.56	0.93	3.22 × 10−87	0.77	2.91 × 10−104	0.17	0.46	0.83	0.15	0.53	0.13	0.23	0.39	0.03
APOC2	Lipid, CAD	rs2288912	1.98 × 10−36	0.85	0.35	0.55	0.83	1.40 × 10−4	6.10 × 10−3	1.38 × 10−6	0.39	0.76	0.24	0.40	0.38	0.84	0.70	0.23	0.57
FNTB	RBC traits	rs7148144	1.90 × 10−22	0.56	0.58	0.91	0.86	0.50	0.48	0.41	0.44	0.38	0.25	0.55	0.16	0.27	0.21	0.68	0.63
CDKN2B	CAD, CAC	rs598664	1.86 × 10−13	0.27	0.56	0.96	0.04	0.46	5.30 × 10−3	0.74	0.30	0.38	0.23	0.71	0.58	0.75	0.05	0.98	0.79
FAM117B	CAD	rs1971739	2.93 × 10−11	0.16	0.05	0.38	4.50 × 10−4	4.00 × 10−3	0.14	0.05	0.13	0.33	0.33	0.82	0.55	0.81	0.94	0.03	0.16
C6orf184	CAD	rs7773213	7.07 × 10−11	0.95	0.47	0.43	8.00 × 10−3	1.70 × 10−3	0.52	0.17	0.63	0.08	0.43	5.74 × 10−5	2.90 × 10−6	0.05	0.43	0.94	0.96
CDKN2BAS_S	CAD, CAC	rs1360590	4.58 × 10−10	0.58	0.45	0.59	0.40	0.86	0.78	0.38	0.42	0.76	0.51	0.62	0.12	0.42	1.78 × 10−5	0.29	0.03
SCARA5	Hemostatic (FVII)	rs7003622	3.70 × 10−8	0.22	0.68	0.29	0.37	0.51	0.49	0.94	0.93	0.51	0.42	0.60	0.27	0.69	0.93	0.03	0.67

P-value of <0.05 is given in bold.

FVII, coagulation factor VII; FVIII, coagulation factor VIII; vWF, von Willebrand Factor; TC, total cholesterol; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; TG, triglycerides; HB, hemoglobin concentration; HCT, hematocrit; MCHC, mean corpuscular hemoglobin concentration; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; RBC, red blood cell count; CAD, clinically apparent coronary artery disease; CAC, coronary artery calcium; SBP, systolic blood pressure; DBP, diastolic blood pressure.