Table 4.
Top trans-eSNP results from GWAS for 83 genes
| Gene | Clinical phenotype | Chr_gene | Top 1 trans-eSNP | Chr_trans-eSNP | Physical location | MAF | P, trans-eSNP | Nearest genesa | Additional trans-eQTL Support? | References |
|---|---|---|---|---|---|---|---|---|---|---|
| VWF | Hemostatic | 12 | rs1354034 | 3 | 56824789 | 0.38 | 5.43 × 10−20 | ARHGEF3 | Y | (25) |
| COL4A2 | CAD, CAC | 13 | rs1354034 | 3 | 56824789 | 0.38 | 7.01 × 10−11 | ARHGEF3 | – | – |
| CITED2 | RBC traits | 6 | rs4909812 | 8 | 139714828 | 0.04 | 9.30 × 10−9 | COL22A1 | Y | (32) |
| CCND3 | RBC traits | 6 | rs727582 | 8 | 116719643 | 0.33 | 3.13 × 10−8 | TRPS1 | – | – |
| LPL | Lipid, CAD | 8 | rs7085130 | 10 | 63159783 | 0.45 | 3.59 × 10−8 | C10orf107 | – | – |
| EPO | RBC traits | 7 | rs723580 | 6 | 46155599 | 0.05 | 4.68 × 10−8 | ENPP4 | – | – |
| PCCB | Hemostatic (fibrinogen) | 3 | rs10802704 | 1 | 236766283 | 0.03 | 4.85 × 10−8 | ZP4 | – | – |
aThe nearest gene to the trans-eSNP is given in bold.
Chr, chromosome; SNP, single-nucleotide polymorphism; MAF, minor allele frequency; CAD, clinically apparent coronary artery disease; RBC, red blood cell; CAC, coronary artery calcium.