FIGURE 1.

Modular structure of fTHPs used in the present study. The parent, fTHP, contains an MMP cleavage site (denoted in yellow; sequence given in Table 1) in between (Gly-Pro-Hyp)₅ repeats (denoted in blue). For the GDK series of peptides, single Gly-Pro-Hyp repeats were replaced by Gly-Asp-Lys (denoted in red). For the KGD series of peptides, single Hyp-Gly-Pro repeats were replaced by Lys-Gly-Asp (denoted in green). To properly accommodate Lys-Gly-Asp, KGD E required modification of the cleavage site sequence (see Table 1).