TABLE 1.
Activation parameters of hKv7.5 channels
hKv7.5 | Control | 100 pm AVP | 500 pm AVP | 1 nm PMA |
---|---|---|---|---|
Gmax, pS/pF | 0.31 ± 0.05 | 0.10 ± 0.03a | 0.07 ± 0.03a | 0.04 ± 0.01a |
V0.5, mV | −42.2 ± 2.3 | −41.6 ± 3.0 | −44.0 ± 2.8 | −49.8 ± 6.1 |
s, mV | 12.9 ± 0.7 | 8.5 ± 0.4a | 7.0 ± 0.7a | 7.5 ± 0.6a |
a Significant difference from control, one-way ANOVA, p < 0.001, n = 9–12.