TABLE 2.

Sequence replacements in the C-tail of the β₁-adrenergic receptor

With the exception of the dopamine receptor-recycling signal, all other signals are located at the distal cytoplasmic tail of the indicated protein. The underlined amino acids denote the crucial elements of the sequence.

Ligand	Accession no.	Sequence	PDZ type	Recycling	PKA- dependent	Reference
β2-AR	NM_000024	RNCSTNDSLL	I	Yes	ND	6
GluR1	NM_000827	SGMPLGATGL	I	Yes	Yes	19, 25
Aquaporin-2	NM_000486	PQSLPRGTKA	I	Yes	Yes	26, 27
μ-Opioid receptor	L22455	LENLEAETAPLP	C-terminal non-PDZ	Rescued δ-opioid receptor recycling	ND	31, 42
Dopamine 1 receptor	NM_000794	360TVSINNNGAAMFSSHHEPRGSIS382	Internal non-PDZ	Rescued δ-opioid-R recycling	ND	32
Ionotropic (GluR2)	NM_000826	NVYGIESVKI	II	NDa	ND	8, 33

^a ND, not determined.