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. 2013 Dec 2;289(4):2361–2370. doi: 10.1074/jbc.M113.523605

FIGURE 3.

FIGURE 3.

CREMα recruits DNMT3a to the CD8 cluster. A, DNMT3a knock-down results in increased CD8A and CD8B mRNA expression in human CD8+ T cells (24 h) when compared with controls (left: CD8A, right: CD8B, first to third lanes). CREMα reduces CD8A and CD8B mRNA expression (24h) (fourth and fifth lanes). DNMT3a knock-down reverses CREMα-mediated suppression of CD8A and CD8B mRNA (24 h) (sixth lane). B, CD8A and CD8B mRNA expression in response to CREMα with or without DNMT3a knock-down are reflected by DNA methylation.