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. 2013 Dec 2;289(4):2361–2370. doi: 10.1074/jbc.M113.523605

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FIGURE 4. — CD8 expression is reflected by H3K27 and H3K9 methylation. CD4⁺ and CD8⁺ T cells from healthy humans and MRL/LPR mice were sorted for the assessment of histone methylation of the CD8 cluster, using ChIP. Murine DN T cells were sorted; human DN T cells were induced by TCR stimulation. In human (left) and murine (right) CD4⁺ T cells, histone H3 was tri-methylated at residues lysine 27 (H3K27me3) (A) and at lysine 9 (H3K9me3) (B) over the entire CD8 cluster. In CD8⁺ T cells from both species, almost no H3K9me3 orH3K27me3 was detected, whereas induced human and murine DN T cells exhibited an increase in H3K27me3 and H3K9me3. Histone H3K9 and H3K27 methylation is more consistent over the murine CD8 cluster, whereas histone H3 methylation peaks around CNS2, -6, -7, and -8 in human DN T cells.