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. 2013 Dec 2;289(4):2361–2370. doi: 10.1074/jbc.M113.523605

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FIGURE 5. — CREMα interacts with G9a mediating chromatin remodeling of the CD8 cluster. A and B, based on histone methylation patterns, the recruitment of G9a to the CD8 cluster has been tested, using ChIP. In both healthy humans (A) and MRL/lpr mice (B), the recruitment of G9a to the CD8 cluster in DN T cells is largely increased when compared with CD8⁺ T cells. C, forced expression of the histone methyltransferase G9a mediates a significant reduction of CD8A and CD8B mRNA expression through a significant increase of H3K9me3 and H3K27me3 (D) (*, indicates p < 0.05).