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Effects of a PKC inhibitor on the transdermal penetration of liposomes in vivo and relative permeability of LY in vitro. Effect of a PKC inhibitor (Ro-31–8425) on (A) Cx43 phosphorylation (green) and transdermal penetration of liposomes (red) in skin treated with IP with liposomes and (B) permeation of LY through cultured cell monolayers treated with ES with liposomes. Bar indicates 100 μm. The data represent the average with standard deviation (n > 3).
