Table 4.

Incidence rate ratios (IRR) of the number of triggered reminders by negative binomial regression models using a generalized estimation equation

	Unadjusted			Adjusted e
	IRR (95% CI)	SE d	p-value	IRR (95% CI)	SE d	p-value
Indiv_MO12a
Group	1.002 (0.895 – 1.121)	0.057	0.98	1.004 (0.903 – 1.116)	0.054	0.94
Time	1.014 (1.001 – 1.023)	0.005	0.002	1.017 (1.008 – 1.026)	0.005	<0.001
Time2	1.002 (1.001 – 1.003)	0.0003	<0.001	1.002 (1.001 – 1.003)	0.0003	<0.001
Group × Time	1.001 (0.995 – 1.008)	0.003	0.73	1.002 (0.995 – 1.009)	0.003	0.56
Indiv_MO6b
Group	1.011 (0.913 – 1.120)	0.053	0.84	1.008 (0.923 – 1.101)	0.045	0.86
Time	1.038 (1.030 – 1.046)	0.004	<0.001	1.044 (1.036 – 1.052)	0.004	<0.001
Group × Time	0.990 (0.980 – 1.001)	0.005	0.066	0.989 (0.978 – 0.9997)	0.005	0.044
Indiv_MO3c
Group	0.990 (0.895 – 1.094)	0.051	0.84	1.013 (0.926 – 1.108)	0.046	0.77
Time	1.036 (1.024 – 1.050)	0.007	<0.001	1.046 (1.031 – 1.062)	0.008	<0.001
Group × Time	0.998 (0.980 – 1.017)	0.009	0.86	0.996 (0.975 – 1.018)	0.011	0.74

^aIndiv_MO12 for the study patients with 12 months’ individual follow-up using exchangeable working correlation structure.

^bIndiv_MO6 for the study patients with six months’ individual follow-up using exchangeable working correlation structure.

^cIndiv_MO3 for the study patients with three months’ individual follow-up using the auto-regressive (AR1) working correlation structure.

^dSemi-Robust Huber/White sandwich estimated standard errors.

^eAdjusted for age, gender, number of diagnoses and number of medications.