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. 2013 Dec 23;9:261. doi: 10.1186/1746-6148-9-261

Table 3.

Mean ± SD of physiological variable measurements by treatment group

Variable Group Immediately prior to premedication Immediately prior to induction Immediately post-induction Minutes post-induction
5 min 10 min 20 min 30 min
Heart rate (beats per min) (N)1
 1
 NA (0)
 117.2 ± 32.6 (22)
 118.0 ± 27.1 (21)
 123.7 ± 26.2 (20)
 119.7 ± 28.7 (18)
 112.9 ± 21.4 (10)
 114.8 ± 18.5 (5)
2
 113.0 ± 31.0 (25)
 112.8 ± 32.2 (25)
 116.3 ± 36.2 (23)
 110.0 ± 28.7 (21)
 112.1 ± 25.4 (19)
 101.8 ± 26.7 (17)
 94.2 ± 18.5 (14)
3
 107.6 ± 28.9 (25)
 96.9 ± 25.8 (25)
 99.5 ± 34.1 (25)
 101.0 ± 30.7 (23)
 100.3 ± 26.3 (24)
 103.4 ± 22.3 (16)
 99.4 ± 19.1 (7)
4
 127.8 ± 31.3 (22)
 135.9 ± 35.0 (22)
 146.8 ± 28.2 (20)
 146.8 ± 30.9 (19)
 141.7 ± 27.4 (18)
 126.7 ± 26.0 (18)
 123.1 ± 20.1 (19)
5
 116.8 ± 18.9 (22)
 145.1 ± 44.0 (22)
 142.9 ± 37.3 (21)
 158.1 ± 32.0 (20)
 134.2 ± 25.2 (21)
 124.2 ± 23.6 (21)
 114.5 ± 23.4 (20)
6
 115.6 ± 33.5 (21)
 88.4 ± 36.9 (21)
 94.9 ± 27.4 (20)
 104.1 ± 26.3 (19)
 102.6 ± 22.3 (19)
 103.1 ± 20.4 (19)
 95.1 ± 18.8 (18)
Statistical results2
 None
 4 > (3, 6); 5 > (2, 3, 6)
 4 > (2, 3, 6); 5 > (3, 6)
 4 > (2, 3, 6); 5 > (1–3, 6)
 4 > (2, 3, 6); 5 > (3, 6)
 4 > (2, 3, 6); 5 > (3, 6)
 4 > (2, 3, 6); 5 > (3, 6)
Respiratory rate (breaths per min)
 1
 NA
 41.6 ± 13.8
 28.6 ± 24.0
 31.2 ± 16.7
 32.3 ± 26.6
 22.6 ± 11.5
 23.5 ± 9.8
2
 41.1 ± 13.7
 36.4 ± 14.9
 26.1 ± 15.5
 27.1 ± 18.7
 30.7 ± 19.9
 32.1 ± 18.4
 27.0 ± 15.2
3
 30.6 ± 13.7
 30.3 ± 13.3
 23.0 ± 15.2
 24.6 ± 11.6
 29.3 ± 11.6
 27.8 ± 10.8
 26.4 ± 15.3
4
 34.8 ± 12.0
 34.4 ± 11.8
 23.9 ± 18.8
 25.7 ± 13.3
 24.9 ± 19.9
 23.3 ± 21.7
 26.5 ± 16.9
5
 28.6 ± 6.2
 29.9 ± 17.5
 12.6 ± 9.8
 17.4 ± 15.3
 17.0 ± 11.6
 14.0 ± 6.3
 12.6 ± 8.6
6
 42.4 ± 17.5
 30.7 ± 23.6
 12.2 ± 4.5
 13.8 ± 6.4
 13.8 ± 7.1
 14.7 ± 6.7
 12.9 ± 5.9
Statistical results2
 6 > 5
 None
 1 > (5, 6)
 (1, 2) > 6
 (1, 2, 3) > 6
 (2, 3) > 5; 2 > 6
 (2, 3, 4) > 5; (2, 4) > 6
Systolic blood pressure (mmHg)
 1
 NA
 148.0 ± 28.8
 128.1 ± 19.9
 128.2 ± 32.8
 127.2 ± 21.5
 115.7 ± 18.2
 112.8 ± 14.8
2
 141.8 ± 21.3
 135.0 ± 30.6
 119.6 ± 24.7
 113.2 ± 24.0
 115.3 ± 28.0
 111.1 ± 20.8
 115.9 ± 24.4
3
 136.6 ± 23.4
 126.2 ± 33.6
 112.3 ± 21.0
 108.8 ± 18.5
 112.2 ± 18.7
 106.9 ± 17.3
 106.1 ± 15.5
4
 129.6 ± 23.1
 137.4 ± 24.9
 122.7 ± 21.3
 108.8 ± 15.3
 106.4 ± 17.3
 105.6 ± 26.7
 108.6 ± 31.8
5
 137.2 ± 22.3
 134.5 ± 16.5
 124.4 ± 15.2
 112.1 ± 17.1
 100.9 ± 11.1
 99.8 ± 14.7
 101.3 ± 13.7
6
 137.1 ± 26.6
 128.9 ± 34.5
 125.9 ± 40.1
 116.2 ± 39.4
 127.9 ± 52.1
 124.5 ± 36.2
 116.6 ± 26.3
Statistical results2
 None
 None
 None
 None
 (1, 6) > 5
 6 > 5
 None
Diastolic blood pressure (mmHg)
 1
 NA
 91.5 ± 33.6
 81.1 ± 21.1
 79.7 ± 32.2
 82.8 ± 22.6
 69.4 ± 14.9
 74.0 ± 23.8
2
 89.0 ± 18.4
 86.8 ± 22.8
 77.1 ± 27.5
 71.2 ± 16.2
 73.3 ± 19.0
 71.8 ± 22.9
 75.1 ± 21.8
3
 92.4 ± 26.1
 76.9 ± 27.4
 70.4 ± 24.0
 63.5 ± 18.5
 63.8 ± 15.4
 57.7 ± 21.3
 58.7 ± 15.5
4
 87.1 ± 25.8
 90.6 ± 28.6
 76.2 ± 17.2
 62.9 ± 11.6
 57.9 ± 15.4
 57.6 ± 19.8
 60.6 ± 21.6
5
 98.8 ± 18.3
 89.0 ± 17.8
 74.3 ± 19.0
 61.3 ± 16.6
 55.1 ± 4.6
 53.9 ± 9.1
 53.2 ± 8.6
6
 98.4 ± 25.0
 91.4 ± 31.3
 90.0 ± 33.6
 76.8 ± 35.2
 88.2 ± 44.4
 79.2 ± 29.2
 71.8 ± 20.5
Statistical results2
 None
 None
 None
 None
 1 > 5; 6 > (3, 4, 5)
 6 > (3, 4, 5)
 (2, 6) > 5
Mean blood pressure (mmHg)
 1
 NA
 114.7 ± 27.1
 100.2 ± 17.7
 101.9 ± 31.7
 99.9 ± 20.8
 88.1 ± 14.8
 90.0 ± 21.4
2
 108.9 ± 17.3
 102.3 ± 21.0
 95.3 ± 24.2
 85.8 ± 16.4
 90.4 ± 26.0
 87.5 ± 21.2
 90.4 ± 24.1
3
 107.8 ± 24.8
 96.2 ± 27.9
 86.3 ± 21.3
 83.7 ± 16.4
 85.5 ± 13.9
 78.4 ± 20.7
 81.1 ± 16.3
4
 103.7 ± 23.8
 109.8 ± 25.2
 94.4 ± 18.7
 78.0 ± 13.6
 77.8 ± 15.4
 76.6 ± 19.1
 77.8 ± 22.0
5
 113.1 ± 20.1
 105.6 ± 14.3
 92.0 ± 18.0
 79.7 ± 17.4
 72.4 ± 8.9
 69.5 ± 9.5
 70.3 ± 10.4
6
 115.1 ± 24.8
 107.1 ± 31.5
 105.1 ± 36.2
 92.6 ± 33.4
 105.6 ± 44.9
 99.5 ± 30.5
 90.9 ± 19.3
Statistical results2
 None
 None
 None
 1 > (4, 5)
 1 > 5; 6 > (4,5)
 6 > (3, 4, 5)
 (2, 6) > 5
Hb Ox Sat (%)
 1
 NA
 NA
 90.0 ± 9.9
 94.3 ± 3.0
 94.5 ± 2.7
 95.9 ± 2.2
 97.3 ± 1.7
2
 NA
 NA
 90.1 ± 6.7
 91.8 ± 6.7
 93.4 ± 3.5
 94.8 ± 2.7
 97.7 ± 2.4
3
 NA
 NA
 93.9 ± 4.3
 94.0 ± 3.9
 94.6 ± 2.7
 94.8 ± 3.2
 97.5 ± 2.4
4
 NA
 NA
 95.7 ± 2.4
 95.8 ± 2.1
 96.7 ± 2.0
 96.8 ± 1.7
 95.4 ± 1.8
5
 NA
 NA
 96.5 ± 1.9
 97.6 ± 1.2
 97.2 ± 1.5
 97.2 ± 1.8
 97.0 ± 1.7
6
 NA
 NA
 95.6 ± 3.6
 96.0 ± 2.4
 95.7 ± 2.6
 96.5 ± 2.6
 96.5 ± 2.6
Statistical results2
 -
 -
 (4, 5, 6) > (1, 2)
 (4, 5, 6) > (1, 2)
 (4, 5, 6) > 2; 5 > 3
 5 > (2, 3)
 None
End-tidal CO2 (%)
 1
 NA
 NA
 28.9 ± 7.9
 31.7 ± 8.3
 32.5 ± 7.9
 36.3 ± 5.5
 40.3 ± 9.2
2
 NA
 NA
 34.8 ± 12.7
 34.1 ± 8.0
 38.2 ± 9.2
 38.0 ± 9.4
 40.4 ± 12.2
3
 NA
 NA
 31.6 ± 9.9
 35.9 ± 9.8
 36.0 ± 7.2
 37.7 ± 9.6
 47.0 ± 9.6
4
 NA
 NA
 34.6 ± 12.2
 37.2 ± 9.4
 36.8 ± 9.9
 36.6 ± 8.7
 38.7 ± 5.7
5
 NA
 NA
 30.5 ± 7.9
 33.7 ± 6.3
 36.5 ± 5.9
 37.4 ± 4.6
 38.4 ± 4.4
6
 NA
 NA
 37.0 ± 9.2
 41.4 ± 7.3
 40.8 ± 9.3
 42.0 ± 8.0
 43.8 ± 8.2
Statistical results1
 -
 -
 None
 6 > 1
 6 > 1
 None
 None
Rectal temp. (deg. F)
 1
 NA
 101.7 ± 0.7
 101.2 ± 0.8
 100.9 ± 0.9
 100.4 ± 0.9
 100.1 ± 1.2
 99.8 ± 1.0
2
 101.4 ± 0.7
 101.3 ± 0.7
 100.8 ± 0.8
 100.4 ± 0.7
 100.1 ± 0.7
 99.8 ± 0.8
 99.5 ± 0.8
3
 101.3 ± 0.8
 100.9 ± 0.7
 100.3 ± 0.8
 100.0 ± 1.0
 99.8 ± 1.3
 99.5 ± 1.3
 99.1 ± 1.6
4
 101.5 ± 0.8
 101.2 ± 0.7
 100.3 ± 1.3
 100.3 ± 0.8
 100.2 ± 0.8
 99.6 ± 0.9
 99.0 ± 1.0
5
 101.7 ± 1.0
 101.3 ± 0.8
 100.6 ± 0.9
 100.4 ± 0.9
 100.3 ± 0.7
 99.9 ± 0.9
 99.2 ± 1.1
6
 101.9 ± 0.6
 101.5 ± 0.9
 100.7 ± 1.3
 100.5 ± 1.2
 100.5 ± 1.3
 100.1 ± 1.6
 100.0 ± 1.5
  Statistical results1 None 1 > 3 1 > 3 1 > 3 None None None

1Number of animals for physiological variables measured at a given time point.

2Includes all statistically significant (p < 0.05) differences between means for treatment groups at a given measurement time point.