Table 1.
SNPs showing suggestive association (p < 0.0001) to BD in our combined (CAMH and IoP) GWAS
| Chr | SNP | bp | A1/A2 | MAF | MAF_UK | MAF_CAN | P (UnAdj) | OR (UnAdj) | P (Adj) | OR (Adj) | P_UK | P_CAN | Gene |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
rs2813164 |
96688031 |
C/T |
0.3017 |
0.286 |
0.3195 |
3.75E-04 |
1.295 |
5.67E-05 |
1.349 |
0.07331 |
0.001371 |
Y0062a |
| 3 |
rs11708571 |
21591377 |
G/A |
0.3062 |
0.3163 |
0.2938 |
1.82E-04 |
0.7633 |
8.66E-05 |
0.7485 |
5.27E-05 |
0.2652 |
ZNF659b,c,d |
| 4 |
rs4689410 |
6344204 |
A/G |
0.3434 |
0.3569 |
0.3275 |
2.04E-05 |
0.7418 |
5.96E-06 |
0.7264 |
0.01966 |
0.0002366 |
PPP2R2Ce,f |
| 6 |
rs215006 |
152755628 |
A/G |
0.2281 |
0.2095 |
0.2185 |
2.78E-04 |
1.335 |
7.83E-05 |
1.38 |
0.003807 |
0.001586 |
SYNE1c |
| 6 |
rs214972 |
152775813 |
T/C |
0.2271 |
0.2219 |
0.2327 |
4.73E-05 |
1.383 |
1.66E-05 |
1.419 |
0.003363 |
0.005299 |
SYNE1c |
| 6 |
rs2623971 |
152831067 |
A/G |
0.2107 |
0.2225 |
0.2348 |
1.86E-05 |
1.42 |
3.52E-06 |
1.481 |
0.004044 |
0.02257 |
SYNE1c |
| 6 |
rs2623966 |
152853674 |
C/T |
0.2122 |
0.2076 |
0.2173 |
1.50E-05 |
1.424 |
3.02E-06 |
1.481 |
0.002348 |
0.002308 |
SYNE1c |
| 6 |
rs2141150 |
152868632 |
C/A |
0.2138 |
0.2063 |
0.2155 |
1.73E-05 |
1.419 |
3.33E-06 |
1.476 |
0.002484 |
0.002721 |
SYNE1c |
| 6 |
rs2695261 |
152869726 |
C/T |
0.2069 |
0.2022 |
0.212 |
2.32E-05 |
1.417 |
4.12E-06 |
1.476 |
0.006699 |
0.001146 |
SYNE1c |
| 9 |
rs7864144 |
101406038 |
G/A |
0.1284 |
0.1294 |
0.1268 |
4.85E-04 |
0.7059 |
8.05E-05 |
0.6674 |
0.0008592 |
0.1271 |
GABBR2f,h |
| 10 |
rs12773173 |
30011304 |
T/C |
0.1028 |
0.1698 |
0.2155 |
1.26E-05 |
0.6902 |
6.56E-05 |
0.7054 |
0.02562 |
8.22E-05 |
SVILg |
| 19 |
rs1483651 |
58689834 |
C/A |
0.1914 |
0.2857 |
0.2734 |
9.70E-06 |
1.389 |
7.55E-06 |
1.41 |
0.05476 |
1.10E-05 |
ZNF274c |
| 19 |
rs4444432 |
58715538 |
G/T |
0.2801 |
0.2868 |
0.2741 |
5.58E-06 |
1.402 |
4.85E-06 |
1.419 |
0.05396 |
4.94E-06 |
ZNF274c |
| 19 | rs7256349 | 58718269 | A/G | 0.281 | 0.3041 | 0.2839 | 4.09E-05 | 1.349 | 4.51E-05 | 1.359 | 0.03677 | 0.0001753 | ZNF274c |
aSNP or locus positive in [29].
bSNP or locus positive in [61].
cSNP or locus positive in [37].
dSNP or locus positive in [28].
eSNP or locus positive in [36].
fSNP or locus positive in Gurling-UCL top 1000 (personal communication).
gSNP or locus positive in [61].
hSNP or locus positive in [69].
Only SNPs included if located at genes with previous GWAS bipolar disorder associations. Chr = chromosome; SNP = single nucleotide polymorphism; bp = base pair (position from p telomere, according to NCBI36/hg18); A1 = allele 1; A2 = allele 2; MAF = minor allele frequency, (also for UK and Canadian (CAN) sets); P(UnAdj) = unadjusted p-value; OR(UnAdj) = unadjusted odds ratio; P(Adj) = adjusted p-value; OR(Adj) = adjusted odds ratio; Gene indicates SNP lies within a known gene. Full list of 68 SNPs showing suggestive association (p < 0.0001) is given in Additional file 1: Table S2.