Panels A and B show the estimates of freedom from progression of disease and overall survival, respectively, among patients who received a dose-adjusted combination of etoposide, doxorubicin, and vincristine with cyclophosphamide, prednisone, and rituximab (DA-EPOCH-R). Panels C and D show the estimates of freedom from progression and overall survival, respectively, among patients who received a short course of the combination therapy with a double dose of rituximab in each cycle (SC-EPOCH-RR). Panels E and F show the estimates of freedom from progression and overall survival, respectively, among patients who had the immunodeficiency-associated variant of Burkitt’s lymphoma.