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. Author manuscript; available in PMC: 2014 Jun 7.
Published in final edited form as: Lab Chip. 2013 Dec 7;13(23):4554–4562. doi: 10.1039/c3lc50698c

Scheme 1.

Scheme 1

Fluidic ECL chip for high throughput screening of metabolite-generated DNA damage. The device consists of a flow cell, and a 2.5 × 2.5 × 0.3 cm pyrolytic graphite chip on which 64 analytical spots containing DNA, metabolic enzymes and light emitting polymer (RuIIPVP) have been fabricated. Lower right box shows a simplified version of the detection chemistry, where DNA(G) = guanines in DNA.