Table 2.
Comparison of IC50 data of the inhibitors with literature reported values
| Inhibitor | Assay | Enzyme source | IC50, µM | Ref. |
|---|---|---|---|---|
| Furafylline | This work | Recombinant P450 | 0.65 ± 0.01 | — |
| Phenacetin O-deethylase activity | HLM | 1.76 ± 0.28 | 49 | |
| Phenacetin O-deethylase activity | Recombinant P450 | 1.64 ± 0.16 | 49 | |
| Metabolomics by LC-MS/MS | HLM | 2.0 | 50 | |
| Phenacetin O-deethylase activity | RLM | 0.48 | 51 | |
| Phenacetin O-deethylase activity | RLM | 0.07 | 35a | |
| Ethoxyresorufin O-deethylation assay | HLM | 6 | 52 | |
| Ethoxyresorufin O-deethylation assay | Recombinant P450 | 6 | 52 | |
| Rhapontigenin | This work | Recombinant P450 | 0.032 ± 0.001 | — |
| Ethoxyresorufin O-deethylation assay | Recombinant P450 | 0.4 | 35b |