Table 1.
Regional genotyped and imputed SNPs achieving the highest significance
| SNP | Position | Alleles (minor/major) | MAF (cases) | MAF (controls) | Odds ratio (95 % CI) | p value | Conditional p value
|
r2
|
Annotation | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs17095355 | rs7099604 | rs17095355 (CHB + CHD) | rs7099604 (CHB + CHD) | rs17095355 (EUR) | rs7099604 (EUR) | ||||||||
| rs921348 | 111707498 | A/G | 0.208 | 0.169 | 1.29 (0.97, 1.70) | 0.026 | 0.927 | 0.953 | 0.99 | 0.51 | 1.00 | 0.41 | Intergenic |
| rs7906904 | 111708193 | A/G | 0.213 | 0.174 | 1.29 (0.98, 1.69) | 0.021 | 0.479 | 0.981 | 0.99 | 0.51 | 0.96 | 0.46 | Intergenic |
| rs17095355* | 111735750 | C/T | 0.204 | 0.166 | 1.29 (0.98, 1.71) | 0.026 | – | 0.917 | – | 0.49 | – | 0.41 | Intergenic |
| rs12569425 | 111758177 | G/A | 0.202 | 0.151 | 1.42 (1.07, 1.88) | 0.011 | 0.219 | 0.568 | 0.75 | 0.70 | 0.62 | 0.62 | Intergenic |
| rs7069128 | 111760075 | A/G | 0.202 | 0.151 | 1.42 (1.07, 1.88) | 0.011 | 0.219 | 0.568 | 0.75 | 0.70 | 0.62 | 0.62 | Intergenic |
| rs7099604 | 111774513 | A/G | 0.199 | 0.146 | 1.45 (1.09, 1.92) | 0.002 | 0.053 | – | 0.49 | – | 0.41 | – | ADD3 |
The most significant genotyped and imputed SNPs as well as the relevant SNPs from the Chinese study are included. The imputed SNPs are italicized. The most significant SNP (rs7099604) in this region is in boldface. The r2 correlation between the SNPs listed and rs17095355 as well as rs7099604 are listed separately. Linkage disequilibrium was determined with respect to two populations of 1000G data, the subjects of Chinese descent (CHB and CHD) and of European descent (EUR, comprised of CEU, FIN, GBR, IBS, TSI)
MAF minor allele frequency
*
SNP associated to BA in an Asian population