Skip to main content
. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: J Med Chem. 2010 Feb 11;53(3):1038–1047. doi: 10.1021/jm901029n

Figure 7.

Figure 7

Correlation of CPT formation half-life (see step e, Scheme 2) at three pH values and hydrophobicity constant (π) of amino acid. The reported half-life of CPT formation in PB in three pH values at 37°C represents the mean ± SD (n=3). Even though the rate of prodrug hydrolysis is dependent upon pH (Figure 6), once prodrug hydrolysis occurs the rate of CPT formation is independent of pH. Slopes: pH 7.4 = 14.89 (r2= 0.9837), pH 7.0 = 17.26 (r2= 0.9783), pH 6.6 = 17.42 (r2= 0.9954).