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. 2012 Dec 5;1(4):1156–1167. doi: 10.3390/cells1041156

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Effects of pan-caspase inhibitors, zVAD-fmk (50 μM) and zD-dcb (100 μM), on the AVD induction (top) and caspase-3 activation (bottom) in HeLa cells treated with anti-Fas antibody (anti-Fas) (A) and STS (B). The mean cell volume of anti-Fas- or STS-treated cells in the absence (filled circles) and presence (filled triangles) of a pan-caspase blocker was normalized to that of non-treated (control: open squares) cells. Each data point represents the mean ± SEM (vertical bar) of 10 observations. *p < 0.05 vs. corresponding control. It is noted that either pan-caspase blocker abolished caspase-3 activation, but not AVD induction in both anti-Fas- and STS-treated cells, and also that the late-phase cell shrinkage observed at ≥4 h after stimulation with anti-Fas or STS was significantly (p < 0.05) suppressed by pan-caspase blockers.