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Illustration of Ire1p activation and inactivation. Unfolded protein accumulation and inositol depletion stimulate BiP/Kar2p release and Ire1p oligomerization. Splicing of HAC1 mRNA is further enhanced by peptide binding to Ire1p and Ire1p clustering. Increased levels of Hac1p upregulate UPR effectors leading to resolution of stress.
