Table 3.
Drug-related adverse events, worst grade per patient during Cycle 1
| Bortezomib (mg/m2) | 0.7 |
1.0 |
1.3 |
1.5 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Toxicities | G1 | G2 | G3 | G1 | G2 | G3 | G1 | G2 | G3 | G1 | G2 | G3 | Total, % (n=23) |
| Hematologic | |||||||||||||
| Thrombocytopenia | 2 | 3* | 2 | 7 (30.4) | |||||||||
| Anemia | 1 | 1 | 1 | 3 (13) | |||||||||
| Non-Hematologic | |||||||||||||
| Nausea | 2 | 5 | 4 | 1 | 2 | 1 | 15 (65.2) | ||||||
| Fatigue | 3 | 1 | 2 | 2 | 1 | 1 | 1 | 11 (47.8) | |||||
| Constipation | 1 | 3 | 2 | 1 | 7 (30.4) | ||||||||
| Anorexia | 1 | 1 | 1 | 2 | 1 | 1 | 7 (30.4) | ||||||
| Diaphoresis / flushing | 3 | 3 | 2 | 8 (34.8) | |||||||||
| Diarrhea | 2 | 2 | 1 | 5 (21.7) | |||||||||
| Vomiting | 1 | 2 | 1 | 1 | 5 (21.7) | ||||||||
| Hyponatremia | 1 | 1 (4–3) | |||||||||||
*
Two Grade 3 and One Grade 4 Thrombocytopenia
Abbreviations: G Grade