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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: Anal Chem. 2013 Nov 22;85(24):11966–11972. doi: 10.1021/ac402906d

Figure 1.

Figure 1

Schematic showing the reactive liquid sample DESI source for MS of protein-ligand complexes. As depicted, a protein solution is infused through a sample transfer capillary, and the emerging droplet containing the protein is exposed to the charged droplets containing ligand molecules from the DESI probe. The sampling can be reversed, with the ligand solution introduced via the sample transfer capillary and the protein sprayed through the DESI probe.