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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: J Med Chem. 2008 Mar 13;51(7):2100–2107. doi: 10.1021/jm701212m

Figure 2.

Figure 2

Effect of ciglitazone (CG) and Δ2CG on AR ablation in LNCaP cells. (A) Dose- and time-dependent effects of CG and Δ2CG on suppressing AR protein expression levels. Cells were exposed to CG or Δ2CG under the indicated conditions in 10% FBS-supplemented medium, and the lysates were subjected to Western blot analysis. (B) Time-dependent effect of CG (60 μM) and Δ2CG (30 μM) on suppressing the mRNA levels of AR. Cells were treated with either agent in 10% FBS-supplemented medium for the indicated times. Total RNA was isolated and subjected to RT-PCR analysis as described in the Experimental Section.