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Transcriptional and post-transcriptional regulation of p53 in miRNA biogenesis. p53 modulates miRNA maturation at not only the transcription step but also the processing step of primary miRNA transcripts and results in production of crosstalk between the p53 network and the miRNA biogenesis machinery in the DDR. Many miRNAs regulated by p53 modulate the DDR by targeting proteins in the DDR, such as cell-cycle progression and apoptosis.
