Table II.
HLA typing, stage of disease, NY-ESO-1-Ab, LAGE-1+/NY-ESO-1+ tumor status, LAGE-1-Ab, and response types of the patients and normal donors evaluated in the study
| Th1/Th2 Spontaneous Response Test by ICSa |
||||||||
|---|---|---|---|---|---|---|---|---|
| Donors | HLA-DR | Stage of Disease |
NY-ESO-1 Ab |
NY-ESO-1+/LAGE-1+ (PCR) | LAGE-1 Ab |
LAGE-197–114 | LAGE-1104–121 | LAGE1b118–135 |
| Patients | ||||||||
| MP1 | 1102 | IV | + | + | – | Th1/Th2 (213, 79) | Th1 (551, 0) | |
| MP2 | 0101, 0401 | IV | + | + | – | Th2 (0, 100) | Th2 (0, 110) | |
| MP3 | 0701, 1320 | IV | + | + | – | Th1 (130, 0) | ||
| MP4 | 1501 | IV | + | + | – | Th1 (101, 18) | ||
| MP5 | 1301, 1302 | IV | + | + | + | Th1/Th2 (505, 80) | Th1/Th2 (885, 70) | |
| MP6 | 0101, 0102 | IV | + | + | + | Th1 (110, 20) | Th1/Th2 (351, 185) | Th1/Th2 (141, 55) |
| MP7 | 0301, 1501 | IV | + | + | + | Th2 (0, 435) | Th2 (0, 543) | Th2 (0, 743) |
| MP8 | 1101, 1301 | IV | + | + | – | Th1/Th2 (341, 221) | Th1/Th2 (211, 81) | |
| MP9 | 0101, 1301 | IV | + | + | + | Th1/Th2 (83, 193) | Th1/Th2 (205, 65) | Th1/Th2 (133, 53) |
| MP10 | 0101, 0102 | IV | + | + | – | Th1 (219, 15) | ||
| MP11 | 0301, 0701 | IV | + | + | – | Th1 (480, 0) | ||
| MP12 | NA | IV | + | + | – | Th1 (270, 0) | ||
| MP13 | NA | IV | + | + | – | Th1 (110, 0) | ||
| MP14 | NA | IV | + | + | – | Th1 (400, 0) | ||
| MP15 | NA | IV | + | + | – | Th1/Th2 (60, 530) | ||
| MP16 | NA | IV | + | + | – | Th1 (170, 0) | ||
| MP17 | NA | IV | – | – | – | |||
| MP18 | NA | IV | – | – | – | |||
| MP19 | NA | IV | – | – | – | |||
| MP20 | NA | IV | – | – | – | |||
| MP21 | NA | IV | – | – | – | |||
| Normal donors | ||||||||
| ND1 | 1401, 1501 | – | ||||||
| ND2 | 0301, 1001 | – | ||||||
| ND3 | 0301, 0701 | – | ||||||
| ND4 | NA | – | ||||||
| ND5 | NA | – | ||||||
| ND6 | NA | – | ||||||
| ND7 | NA | – | ||||||
| ND8 | NA | – | ||||||
| ND9 | NA | – | ||||||
| ND10 | NA | – | ||||||
| ND11 | NA | – | ||||||
| ND12 | NA | – | ||||||
| ND13 | NA | – | ||||||
| ND14 | NA | – | ||||||
| ND15 | NA | – | ||||||
| ND16 | NA | – | ||||||
a
Number of IFN-γ–producing CD4+ T cells per 105 CD4+ T cells, number of IL-5–producing CD4+ T cells per 105 CD4+ T cells. Background has been subtracted. NA, not available; ND, normal donor.