. Author manuscript; available in PMC: 2014 Jan 24.

Published in final edited form as: Cancer Chemother Pharmacol. 2009 Feb 17;64(4):803–810. doi: 10.1007/s00280-009-0931-y

Table 3.

Treatment Schedules

24 hour infusion of Bryo every 3 weeks
Dose level	Bryo (mcg/m²)	Cisplatin (mg/m²)	# of patients (Total/Eval)	Cycles (Total)
1	10	50	3/3	11
2	15	50	3/3	6
3	20	50	3/3	10
4	25	50	3/3	9
5	30	50	3/3	5
6	30	75	3/3	7
7	40	75	3/3	8

1 hour infusion of Bryo every 3 weeks
Dose level	Bryo (mcg/m²)	Cisplatin (mg/m²)	# of patients (Total/Eval)	Cycles (Total)
8	40	50	3/3	9
9	50	50	3/3	6
10	65	50	6/3	19
11	80	50	7/6	13

1 hour infusion of Bryo every 2 weeks
Dose level	Bryo (mcg/m²)	Cisplatin (mg/m²)	# of patients (Total/Eval)	Cycles (Total)
1A	40	50	7/6	28
2A	30	50	6/6	28