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. 2013 Aug 20;2:147. Originally published 2013 Jul 4. [Version 2] doi: 10.12688/f1000research.2-147.v2

PMC3901452.1; 2013 Jul 4
PMC3901452.2; 2013 Aug 20

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Copyright: © 2013 Clutterbuck AL et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).

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Figure 1. — Curcumin significantly increases chondrocyte death after 24 hours ( A) at 50μM and 100μM compared to control indicated by *** ( p<0.001). After 48 hours ( B) and five days ( C), curcumin (25μM) significantly increases chondrocyte death compared to controls. The nitric oxide donor, sodium nitroprusside (SNP) (50mM) also significantly increases chondrocyte death at 24 hours, 48 hours, and five days ( p<0.001) compared to control. DMSO at concentrations found in the 100μM curcumin treatment has no effect on chondrocyte death. Results are expressed as the mean number of dead cells per field of view per treatment ± SEM. Data presented are from 5 different animals with 2 technical replicates per animal.