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. 2013 Aug 20;2:147. Originally published 2013 Jul 4. [Version 2] doi: 10.12688/f1000research.2-147.v2

PMC3901452.1; 2013 Jul 4
PMC3901452.2; 2013 Aug 20

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Copyright: © 2013 Clutterbuck AL et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).

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Figure 3. — Control column indicates cartilage discs incubated in the culture medium alone. Values are reported as the mean of three animals per treatment ± SEM. Data are from 3 different animals, with three technical replicates per animal. Significance compared to control is indicated by *** ( p<0.001). Sodium nitroprusside (SNP) (50mM) significantly increases PG release compared to control ( p<0.001). Curcumin does not alter PG release from the explants compared to control at concentrations of 12µM, 25µM or 50µM. PG loss is expressed as sulfated glycosaminoglycan (GAG) release.